| Entry |
|
|---|
| Name |
Dydrogesterone (JP18/USP/INN);
Duphaston (TN);
Gynorest (TN) |
|---|
| Formula |
C21H28O2
|
|---|
| Exact mass |
312.2089
|
|---|
| Mol weight |
312.4458
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Hormonal agent
DG02004 Progesterone
DG01666 Progesterone receptor agonist
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 2478 |
|
|---|
| Efficacy |
Menstruation disorder agent, Progesterone receptor agonist |
|---|
| Comment |
Progestin
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04914 | Progesterone-mediated oocyte maturation |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07226 | Progesterone, androgen and estrogen receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
G GENITO URINARY SYSTEM AND SEX HORMONES
G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
G03D PROGESTOGENS
G03DB Pregnadien derivatives
G03DB01 Dydrogesterone
D01217 Dydrogesterone (JP18/USP/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
24 Hormones
247 Estrogen and progesterone preparations
2478 Synthetic progestins
D01217 Dydrogesterone (JP18/USP/INN)
Drug groups [BR:br08330]
Hormonal agent
DG02004 Progesterone
D01217 Dydrogesterone
DG01666 Progesterone receptor agonist
D01217 Dydrogesterone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D01217 Dydrogesterone
Drug classes [BR:br08332]
Endocrine and hormonal agent
DG02004 Progesterone
D01217 Dydrogesterone
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C3 (PGR)
D01217 Dydrogesterone (JP18/USP/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01217 Dydrogesterone
D01217 Dydrogesterone tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01217
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 23
1 C1x C 26.5729 -16.7810
2 C5x C 26.5729 -18.1468
3 C2x C 27.7586 -18.8297
4 C1x C 27.7586 -16.0981
5 C1z C 28.9374 -16.7810
6 C2y C 28.9316 -18.1468
7 C2x C 30.1115 -18.8349
8 C2x C 31.2972 -18.1569
9 C1y C 30.1231 -16.1032
10 C1y C 31.2972 -16.7941
11 C1x C 31.3196 -14.0695
12 C1x C 30.1343 -14.7410
13 C1z C 32.4914 -14.7599
14 C1y C 32.4776 -16.1298
15 C1x C 34.8506 -16.0837
16 C1x C 34.8643 -14.7835
17 C1y C 33.6847 -14.0867
18 C5a C 33.6983 -12.7209
19 C1a C 34.8880 -12.0498
20 O5a O 32.5223 -12.0262
21 O5x O 25.3903 -18.8304
22 C1a C 28.9251 -15.4151
23 C1a C 32.4778 -13.3871
BOND 26
1 11 12 1
2 12 9 1
3 2 3 1
4 3 6 2
5 5 6 1
6 6 7 1
7 7 8 2
8 13 14 1
9 15 16 1
10 16 17 1
11 17 13 1
12 14 15 1
13 8 10 1
14 17 18 1 #Up
15 9 5 1
16 18 19 1
17 5 4 1
18 18 20 2
19 4 1 1
20 2 21 2
21 5 22 1 #Down
22 1 2 1
23 9 10 1
24 10 14 1
25 13 11 1
26 13 23 1 #Up
|
|---|
