KEGG   DRUG: Dydrogesterone
Entry
D01217                      Drug                                   
Name
Dydrogesterone (JP18/USP/INN);
Duphaston (TN);
Gynorest (TN)
Formula
C21H28O2
Exact mass
312.2089
Mol weight
312.4458
Structure
Simcomp
Class
Hormonal agent
 DG02004  Progesterone
 DG01666  Progesterone receptor agonist
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2478
ATC code: G03DB01
Product: D01217<JP>
Efficacy
Menstruation disorder agent, Progesterone receptor agonist
Comment
Progestin
Target
NR3C3 (PGR) [HSA:5241] [KO:K08556]
  Pathway
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07226  Progesterone, androgen and estrogen receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03D PROGESTOGENS
    G03DB Pregnadien derivatives
     G03DB01 Dydrogesterone
      D01217  Dydrogesterone (JP18/USP/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   247  Estrogen and progesterone preparations
    2478  Synthetic progestins
     D01217  Dydrogesterone (JP18/USP/INN)
Drug groups [BR:br08330]
 Hormonal agent
  DG02004  Progesterone
   D01217  Dydrogesterone
  DG01666  Progesterone receptor agonist
   D01217  Dydrogesterone
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D01217  Dydrogesterone
Drug classes [BR:br08332]
 Endocrine and hormonal agent
  DG02004  Progesterone
   D01217  Dydrogesterone
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C3 (PGR)
     D01217  Dydrogesterone (JP18/USP/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01217  Dydrogesterone
  D01217  Dydrogesterone tablets
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01217
Other DBs
CAS: 152-62-5
PubChem: 7848280
ChEBI: 31527
LigandBox: D01217
NIKKAJI: J3.272G
KCF data

ATOM        23
            1   C1x C    26.5729  -16.7810
            2   C5x C    26.5729  -18.1468
            3   C2x C    27.7586  -18.8297
            4   C1x C    27.7586  -16.0981
            5   C1z C    28.9374  -16.7810
            6   C2y C    28.9316  -18.1468
            7   C2x C    30.1115  -18.8349
            8   C2x C    31.2972  -18.1569
            9   C1y C    30.1231  -16.1032
            10  C1y C    31.2972  -16.7941
            11  C1x C    31.3196  -14.0695
            12  C1x C    30.1343  -14.7410
            13  C1z C    32.4914  -14.7599
            14  C1y C    32.4776  -16.1298
            15  C1x C    34.8506  -16.0837
            16  C1x C    34.8643  -14.7835
            17  C1y C    33.6847  -14.0867
            18  C5a C    33.6983  -12.7209
            19  C1a C    34.8880  -12.0498
            20  O5a O    32.5223  -12.0262
            21  O5x O    25.3903  -18.8304
            22  C1a C    28.9251  -15.4151
            23  C1a C    32.4778  -13.3871
BOND        26
            1    11  12 1
            2    12   9 1
            3     2   3 1
            4     3   6 2
            5     5   6 1
            6     6   7 1
            7     7   8 2
            8    13  14 1
            9    15  16 1
            10   16  17 1
            11   17  13 1
            12   14  15 1
            13    8  10 1
            14   17  18 1 #Up
            15    9   5 1
            16   18  19 1
            17    5   4 1
            18   18  20 2
            19    4   1 1
            20    2  21 2
            21    5  22 1 #Down
            22    1   2 1
            23    9  10 1
            24   10  14 1
            25   13  11 1
            26   13  23 1 #Up

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